RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an subterranean weapons facility in Syria employed by the IS group, as stated by the UK Ministry of Defence.
The location, pinpointed through intelligence, was believed to be containing munitions and bombs, the statement said, and was positioned in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to strike a number of access tunnels providing entry to the depot... preliminary assessments suggest the target was engaged successfully," the ministry announced.
There was no evidence of any harm to civilians in the attack on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
Daesh - alternatively referred to as ISIS - established jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and resolve to work closely with our partners, to stamp out any re-emergence of IS and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the minister said.
UK warplanes have performed surveillance missions over Syrian airspace to "forestall any efforts to regroup" of Islamic State after its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I extend gratitude to all the members of British forces participating in this strike for their professionalism and their courage," he added. "They were among thousands of UK service members on duty over the festive period. This operation, to eliminate terrorist threats who threaten our way of life, highlights how British military are prepared to act, all year round, protecting the UK at home and influential overseas."
Last December, the United States armed forces conducted what it termed a "large-scale strike" targeting Daesh sites in Syria, after an assault claimed the lives of two American soldiers and a local interpreter in Palmyra.
The UN estimates Daesh still boasts between 5,000 and 7,000 fighters in Iraq and Syria.
